The crude polypeptide extract of bovine pineal glands, epithalamin, is the source of the tetrapeptide isolate known as Epithalon. Professor Vladimir Khavinson created Epithalon in the 1980s. Studies suggest that epithalons may cause telomeres to lengthen, which delays cell aging in the immune and reproductive systems and has been posited to increase animal longevity. Epithalon has been widely researched in Russia and has been hypothesized to exhibit downstream anti-aging, sleep-inducing, anti-cancer, and disease-fighting characteristics.
Epithalon Peptide: What is it?
Epithalon is a manufactured derivative of the naturally occurring tetrapeptide epithalamin in cattle pineal glands. Professor Vladimir Khavinson, currently president of the Saint Petersburg Institute of Bioregulation and Gerontology, found it in the late 1980s. Other names for it include Epitalon and Epithalone.
Epithalon is a tetrapeptide that contains four amino acids, similar to epithalamin. The consensus is that it may help keep somatic cell telomeres at length by potentially stimulating and elongating them. Among Epithalon’s many possible impacts are its potential to upregulate telomerase activity, which may exert anti-aging impacts on cells, possibly inhibiting carcinogenesis, and may extend lifespan of cells.
Research indicates that Epithalon may prolong the life of cell cultures and animals by suppressing the CCl11 and HMGB1 genes. In addition to its anti-tumor activities in colorectal and breast cancer, the peptide is hypothesized to exhibit antioxidant properties and inhibit carcinogenic receptor expression.
Investigations purport that the Epithalon may potentially control the expression of inflammatory biomolecules such as cytokines and C-reactive proteins. This indicates its potential relevance in research in the context of inflammatory bowel diseases and rheumatoid arthritis.
Finally, Epithalon is believed to be an important part of the endocrine system because it is thought to increase levels of endogenous hormones like melatonin (which may help to regulate the sleep cycle) and gonadotropic hormones (FSG, LG, prolactin) (which are involved in reproductive activities) that normally decrease over time.
Epithalon Peptide Potential
Because of its classification as a research chemical, Epithalon is only offered for use in controlled laboratory settings and in vitro experiments. It has not been approved by any foreign regulatory body. None of the substances mentioned in this paper have been approved for human or animal consumption and may, therefore, not be acquired or utilized by unlicensed individuals. Previous studies and experiments have noted the following properties of Epithalon, which may interest researchers.
Epithalon Peptide and Cell Aging
There is a lot of interest in studying Epithalon from an anti-aging perspective since telomeres shorten over time, and the peptide has been hypothesized by scientists to increase telomerase activity, which lengthens telomeres:
- The authors of a 2003 research by Khavinson et al. speculated that Epithalon might “prolong the lifespan of cell populations” after suggesting that it promoted telomerase activity and lengthened telomeres in telomerase-negative fetal fibroblast cultures.
- Epithalon appeared to have increased rats’ longevity when subjected to natural and continuous light, according to Russian research from 2007.
- Synthetic Epithalon is generated from the hormone epithalamin, which was the focus of a 2003 research that suggested it may increase the longevity of older research models who took part in the experiment by acting as a “positive effect” on their immunological, cardiovascular, endocrine, and neurological systems.
- Epithalamin was linked to a “geroprotective effect” and seemed to have enhanced longevity in a randomized experimental study that lasted 12 years. The animal models in the research had heart disease and were experiencing accelerated cardiovascular system cell aging.
Research models of aging cardiovascular systems were presented with Epithalon for two to three years seemed to have a death rate that was 1.6 to 1.8 times lower than the control group, as suggested by research published in 2011.
Epthalon Peptide and Sleep Cycle Regulation
Researchers are interested in Epithalon’s possible sleep-regulating impacts because, as mentioned, it may potentially raise melatonin levels, which may play a significant role in regulating sleep cycles.
Investigations purport that Epithalon may potentially restore a normal hormone circadian rhythm in aged animal models and mayn raise melatonin levels at night in models of pineal gland functional insufficiency. According to the results, Epithalons seem to potentially increase the rate of REM sleep, which, in turn, might impact several physiological impacts within the organism.
Epithalon Peptide and Immunity
Findings imply that Epithalon may potentially aid in cytokine and C-reactive protein level regulation due to its antioxidant potential. Because of this, Epithalon has attracted much attention from researchers looking for a way to approach inflammatory diseases, including ulcerative colitis and arthritis.
It has been hypothesized that Epithalon may potentially suppress the expression of carcinogenic receptors and have considerable anti-tumor actions. According to a 1997 study article, Epithalon presentation appeared to have helped restore cellular immunity and reduced tumor growth in animal models of ovarian, uterine, and cervical cancer.
This concise overview of Epithalon properties should serve as a good jumping-off point for academics looking to identify important areas that might benefit from additional investigation.
Buying Epithalon Peptide Online
Researchers interested in purchasing research peptides for sale are encouraged to visit the Core Peptides website for the highest-quality, most affordable compounds.
References
[i] Medical Professional Monograph Epithalon. (2022). https://peptidesociety.org/wp-content/uploads/2018/07/Epithalon-Monograph-Final.pdf
[ii] Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728. PMID: 12937682.
[iii] Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020 Jan 30;25(3):609. doi: 10.3390/molecules25030609. PMID: 32019204; PMCID: PMC7037223
[iv] Khavinson VKh, Kuznik BI, Tarnovskaia SI, Lin’kova NS. [Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data]. Adv Gerontol. 2014;27(3):399-406. Russian. PMID: 25826983.
[v] Anisimov VN, Arutjunyan AV, Khavinson VK. Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals. Neuro Endocrinol Lett. 2001;22(1):9-18. PMID: 11335874.
[vi] Anisimov VN, Khavinson VK, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer. 2002 Sep 1;101(1):7-10. doi: 10.1002/ijc.10570. PMID: 12209581.
[vii] Labunets IF, Butenko GM, Korkushko OV, Shatilo VB. Effect of epithalamin on the rhythm of immune and endocrine systems functioning in patients with chronic coronary disease. Bull Exp Biol Med. 2007 Apr;143(4):472-5. doi: 10.1007/s10517-007-0159-y. PMID: 18214303.
[viii] Khavinson VKh, Morozov VG. Geroprotektornaia éffektivnost’ timalina i épitalamina [Geroprotective effect of thymalin and epithalamin]. Adv Gerontol. 2002;10:74-84. Russian. PMID: 12577695.
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