Mirror Review
December 19, 2025
The Genesis Mission, officially launched on November 24, 2025, is a national initiative to increase American scientific productivity within a decade.
By fusing the Department of Energy’s (DOE) 17 National Laboratories with frontier artificial intelligence, this “Manhattan Project for the AI age” aims to secure U.S. leadership in energy, national security, and scientific discovery.
On December 18, 2025, the U.S. DOE officially announced collaboration agreements with 24 pioneering organizations.
Based on their official releases, here is how the top partners are contributing to the Genesis Mission and benefiting the Department of Energy.
List of 9 Key Tech Giants Collaborating with the US DOE
1. OpenAI: Stress-Testing “Science-Ready” AI
OpenAI is integrating its frontier models directly into the national laboratory ecosystem for high-stakes research.
- Key Benefit: They are deploying advanced reasoning models on the Venado supercomputer at Los Alamos National Laboratory to tackle complex simulation challenges.
- Unique Contribution: They organized a “1,000 Scientist AI Jam Session” across nine labs, allowing researchers to “stress-test” AI on real-world scientific problems. They are also collaborating on fusion energy modeling and developing safety evaluations for bioscience research.
2. NVIDIA: Building the Hardware Backbone
NVIDIA is serving as a primary infrastructure partner, ensuring the DOE has the raw computing power needed for massive AI workloads.
- Key Benefit: Alongside Oracle, they are building the Department’s largest supercomputer for scientific research at Argonne National Laboratory.
- Unique Contribution: They are supporting seven new computing systems across Argonne and Los Alamos. Their “Genesis” MOU focuses on applying AI to nuclear fission/fusion, digital twins for manufacturing, and quantum computing research.
3. Anthropic: AI Agents for the Lab Bench
Anthropic is focusing on integrating its “Claude” AI assistant directly into scientific workflows to act as a hands-on partner for researchers.
- Key Benefit: They are developing Model Context Protocol servers that connect Claude directly to scientific instruments, effectively giving the AI “hands” to assist with experiments.
- Unique Contribution: Their focus is on three pillars: Energy Dominance (speeding up permitting reviews and nuclear tech), Life Sciences (pandemic early-warning systems), and Scientific Productivity (enabling Claude to read and synthesize 50 years of DOE research).
4. Google DeepMind: Specialized “AI Co-Scientists”
Google DeepMind is providing the DOE Genesis Mission with specialized AI models designed to solve specific, complex scientific problems.
- Key Benefit: They launched “AI co-scientist,” a multi-agent tool built on Gemini that helps researchers generate novel hypotheses and research proposals in days rather than years.
- Unique Contribution: Future access (starting 2026) to proprietary models like AlphaEvolve (for designing advanced algorithms), AlphaGenome (for crop resistance and biofuels), and WeatherNext (for hyper-local weather forecasting).
5. Google Public Sector: The Secure “Big Team Science” Platform
While DeepMind provides the models, Google Public Sector provides the secure environment to run them.
- Key Benefit: They are deploying Gemini for Government, a secure and accredited platform that allows national labs to use commercial AI tools on sensitive government data.
- Unique Contribution: They are enabling “Deep Research” capabilities that can autonomously scan decades of scientific literature to find hidden connections, facilitating a “Big Team Science” approach that connects different DOE facilities.
6. Oracle: Critical Infrastructure & Data Architecture
Oracle is partnering with the DOE’s Genesis Mission to ensure the data structures and cloud infrastructure can handle the mission’s scale.
- Key Benefit: In collaboration with NVIDIA, Oracle is providing the cloud infrastructure for the massive new supercomputer at Argonne National Laboratory.
- Unique Contribution: Their agreement focuses on data architecture and sovereignty, ensuring that the “American Science and Security Platform” has a robust, domestic foundation for training and deploying responsible AI.
7. AWS (Amazon Web Services): Nuclear Innovation at Scale
AWS is using its cloud dominance to modernize specific high-value sectors like nuclear energy.
- Key Benefit: They are collaborating with Idaho National Laboratory (INL) to build an “AI-Powered Nuclear Reactor Design & Analysis Platform,” using AI agents to compress reactor design cycles from years to months.
- Unique Contribution: AWS committed $50 billion to government-focused AI infrastructure and is deploying “AWS AI Factories,” which are hybrid systems that bring cloud AI capabilities directly into secure, on-premises government facilities.
8. CoreWeave: The Dedicated AI Cloud
CoreWeave is providing specialized, high-performance cloud infrastructure designed exclusively for AI workloads, offering an alternative to general-purpose clouds.
- Key Benefit: They are offering a “purpose-built AI cloud platform” that ensures predictable performance for massive scientific simulations that general clouds might struggle to handle efficiently.
- Unique Contribution: Through their CoreWeave Federal unit, they are delivering a FedRAMP-ready environment that allows the DOE to run sensitive “multi-generation hardware” workloads with high resilience and security.
9. Accenture: The Master Integrator
Accenture is acting as the architect for the “American Science and Security Platform,” ensuring all these disparate tools work together.
- Key Benefit: They are responsible for the platform design and enterprise architecture, ensuring that tools from Google, OpenAI, and others can technically integrate with DOE systems.
- Unique Contribution: Their focus is on Data Curation, cleaning and readying the DOE’s massive datasets so they can be securely accessed by AI models, and automating scientific workflows to create a seamless “closed-loop” discovery process.
The “American Science and Security Platform”
Central to the Genesis Mission is a closed-loop AI environment that serves as a shared national instrument. It integrates:
- The 17 DOE National Laboratories: Uniting the expertise of 40,000 scientists and engineers.
- Supercomputing Power: Combining the world’s fastest exascale computers with accredited, secure commercial clouds.
- Massive Datasets: Leveraging over 100 petabytes of unique federal scientific data.
- AI Agents: Utilizing specialized models to automate experimental design, run complex simulations, and generate predictive research models.
Operational Milestones of the Genesis Mission
Under the leadership of Energy Secretary Chris Wright and US Genesis Mission Director Dr. Darío Gil, the DOE is moving quickly.
Within the next 60 days, the department will identify 20 initial national challenges to demonstrate initial operating capabilities for at least one major challenge within 270 days.
End Note
The Genesis Mission represents a fundamental shift in how we address the world’s most complex problems.
By uniting the nation’s greatest scientific minds with the world’s most advanced AI, this partnership will present outputs that were once thought impossible.
Looking ahead, the work that starts today will redefine American leadership in AI and write the next century of global progress.
Maria Isabel Rodrigues
